Facts About Polynucleotides

Duration: | Approx. 15–30 minutes per Session |
Anesthesia: | Local anesthesia using anesthetic cream |
Aftercare: | Use sunscreen for a few days; avoid tanning beds, saunas, and exercise |
Social compatibility: | Immediately |
Price: | Starting at CHF 600 |
In aesthetic medicine, there is no single path to beautiful skin—instead, there is a suitable approach for every area. If, for example, the lips or cheeks lack volume or shape, fillers such as Hyaluronic acid remain the first choice. When the goal is to improve the skin quality itself and give it new freshness and elasticity, however, we are increasingly using biostimulators such as Polynucleotides.
At KALEIDOSCOP aesthetic in Zurich, we use these active ingredients specifically for Skin rejuvenation. Polynucleotides are among the most exciting developments in regenerative aesthetics: they stimulate your skin’s self-renewal rather than merely plumping it up temporarily. With this minimally invasive procedure, we address fine lines or a tired complexion not just on the surface, but from the inside out.
The best way to determine what your skin truly needs is through a personal consultation. Our team of experienced specialists will assess your skin and let you know whether treatment with Polynucleotides is the right solution for you. Please feel free to schedule an appointment for a no-obligation consultation.
Information on Polynucleotides
Definition of Polynucleotides
Polynucleotides are natural molecular chains consisting of many (Greek “poly”) individual nucleotides. These nucleotides are the building blocks of our DNA and act directly at the cellular level. They are classified as so-called biostimulators: They stimulate cell activity and thus support the Skin’s natural regenerative capacity.
We harness this ability in aesthetic medicine and use it specifically for Skin rejuvenation. Essentially, this is a principle derived from biohacking: Instead of intervening from the outside—such as through surgery—we activate the self-renewal process that has long been inherent in your skin. Polynucleotides stimulate the body’s own collagen formation and the production of Elastin—the two substances that keep your skin firm and elastic but are broken down as you age. At the same time, they hydrate the tissue and improve the skin structure. This targeted Skin regeneration makes your skin look fresher and healthier.
Specifically, Polynucleotides work on several levels simultaneously:
- They support the natural regeneration of the tissue.
- They promote the activity of fibroblasts (collagen-producing skin cells).
- They intensely hydrate the tissue.
- They improve elasticity and firmness.
- They protect against oxidative stress and free radicals.
- They improve microcirculation and, as a result, Skin quality.
Reasons for Treatment with Polynucleotides
There are many good reasons to undergo treatment with biostimulators. People often choose Polynucleotides because they
- promote genuine cellular renewal rather than just acting on the surface,
- are versatile—for example, to improve skin structure or reduce fine Wrinkles,
- can be used on various parts of the body (from the face to the hands),
- look very natural without altering facial features, and
- ensure long-lasting results through genuine cell renewal.
Just tell us what kind of change you’d like to see in your skin. We’d be happy to advise you on the method that’s right for you during a personal consultation.
The Goal of Polynucleotides Treatment
Our goal is to naturally counteract skin aging through polynucleotide treatment. Polynucleotides allow us to sustainably improve your skin quality and reduce visible signs of aging, such as fine lines and wrinkles.
Depending on the area treated, additional benefits may occur: dark circles under the eyes can be visibly reduced, the skin on the décolletage becomes firmer, and sun damage on the hands fades.
As with all treatments, it is important to us that the changes are harmonious and suit you. To ensure this, our specialists take plenty of time and tailor the treatment precisely to your needs.
The Polynucleotides Treatment Process
Preparing for the Treatment
It all begins with a personal consultation at our clinic in Zurich. During this consultation, you’ll have the opportunity to tell us, at your own pace, what you hope to achieve for your skin. We’ll examine your skin and work with you to determine which areas are suitable for Polynucleotide treatment. Based on this assessment, we’ll develop a personalized treatment plan. Of course, we’ll also discuss costs and potential Side effects, and provide you with clear information about any factors that might preclude treatment—such as pre-existing medical conditions.
Conducting the Polynucleotides Treatment
Before the treatment, we cleanse your skin and apply an anesthetic cream. It takes effect in about 20 to 30 minutes and numbs the areas to be treated. We then use very fine needles to precisely inject the active ingredient into your skin—at short intervals and only a few millimeters deep. Thanks to Anesthesia, you’ll feel little more than a slight prick. You’ll lie relaxed on the treatment table throughout the procedure. Depending on the size of the area, the entire process takes 15 to 30 minutes.
Aftercare
To finish, we soothe your skin—using either a mask or light therapy, depending on the area. Afterward, you can go straight home and resume your normal daily routine; no downtime is necessary. Minor redness or swelling at the injection sites is normal and usually disappears within one to two days. For the first few days, we recommend that you avoid tanning beds, saunas, and exercise. You should also protect your skin well from the sun, preferably with SPF 50+.

Reviewed by Dr. Christian Köhler
Dr. Christian Köhler, general practitioner, MBA, and certified expert in Zurich, has more than 22 years of operational experience in aesthetic medicine. The information presented on this page has been personally reviewed by him and meets the highest medical standards.

Frequently Asked Questions About Polynucleotide Treatment
For which areas are Polynucleotides suitable?
Polynucleotides are well-suited for the face—especially the sensitive eye area—as well as the neck, décolletage, and hands.
What is the difference between Polynucleotides and Fillers?
Fillers like Hyaluronic acid work by adding volume—they plump up the skin and reshape contours. Polynucleotides take a different approach, triggering change from within through cellular renewal. Your facial features remain unchanged, while your skin gains freshness and elasticity.
How many Polynucleotide treatments are required?
For natural and long-lasting results, we at KALEIDOSCOP aesthetic recommend a course of three Sessions, ideally spaced two weeks apart. This course can be repeated twice a year.
When will the first results be visible?
Initial changes are often visible shortly after treatment. However, the actual skin renewal takes some time: The effects unfold over the following weeks and become increasingly noticeable.
How long do the results of a polynucleotide treatment last?
Based on our experience, the results last about six to twelve months—depending on skin texture and lifestyle.
Is polynucleotide treatment painful?
No. At KALEIDOSCOP aesthetic in Zurich, we use extremely fine needles and apply an anesthetic cream beforehand. This way, you’ll hardly feel the injections.
Are there any risks or Side effects?
Polynucleotides are considered very safe and, as a naturally derived active ingredient, are well tolerated. You may experience temporary mild redness, swelling, or small bruises at the injection sites. These are natural skin reactions that subside on their own.
Can Polynucleotides be combined with other aesthetic treatments?
Yes, and very effectively. We particularly recommend combining them with TotalSkin Solution, an innovative method for the systematic treatment of multiple skin layers. During a personal consultation, we’ll advise you on which treatments complement your skin best.
How much does a Polynucleotides treatment cost in Zurich?
The cost depends on the scope and complexity of the treatment, which vary depending on your skin condition and the treatment area. A single treatment costs CHF 600, and a course of three Sessions costs CHF 1,500. After a personal consultation, we’ll provide you with a customized quote.
Additional treatments
Tödistrasse 7
8002 Zurich
+41 43 234 5000
+41 78 480 24 24
contact@kaleidoscop.ch
TUE – FRI
9 am – 1:30 pm
2:30 pm – 7 pm



